Masakazu Inoue

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Human dental plaque consists of a wide variety of microorganisms, some of which are believed to cause systemic infections, including abscesses, at various sites in the body. To confirm this hypothesis experimentally, we examined the abscess-forming ability of native dental plaque in mice, the microbial features of the infectious locus produced by the(More)
OBJECTIVE Bacterial biofilms cause serious problems, such as antibiotic resistance and medical device-related infections. Recent reports indicate that Bacillus species potentially form biofilms and cause nosocomial bacteremia via catheter infection. Our objective was to investigate the relationship between nosocomial bacteremia caused by Bacillus species(More)
BACKGROUND Two rotavirus vaccines have recently been licensed for use in >80 countries worldwide but not in Japan. To assess the value of introducing rotavirus vaccination in Japan, data on the burden of rotavirus disease are needed. METHODS To describe the epidemiology of severe rotavirus disease among Japanese children aged <5 years, we examined(More)
AIM To assess the critical tooth number (CTN) required for prevention of subjective dysphagia caused by oral impairments and to evaluate the relationship between this CTN and mortality. METHODS The baseline study was performed with residents aged 40-89years (n=5,643; 2224 men and 3419 women) in Miyako Islands, Okinawa, in 1987. Dental examinations were(More)
Guillain-Barré syndrome (GBS) is well known as presenting with acute immune-mediated polyneuropathies, with strong associations with antecedent infections. Several variant forms of GBS have been described, including acute inflammatory demyelinating polyneuropathy, acute motor axonal neuropathy, acute motor-sensory axonal neuropathy, and sensory GBS. We(More)
Immunodominance of conformational epitopes over linear ones in four proteins was quantified making use of the B-cell hybridoma technology. The proteins were immunized in their native forms into BALB/c mice, and clonal frequencies of B-cell hybridomas that produce antibodies to the native and denatured forms were determined, using ELISA and immunoblotting.(More)
Human dental plaque is thought to contribute to disease, not only in the oral cavity but also at other body sites. To investigate the pathogenicity of dental plaque in tissues remote from the mouth, we examined the ability of human supragingival dental plaque to induce infective endocarditis (IE) in rats. In total, 15 out of 27 catheterized rats survived(More)
BACKGROUND Few data are available for the recent occurrence of Mycoplasma infections in children in Japan. The purpose of the present study was therefore to identify the prevalence of Mycoplasma infections in children in Japan. METHODS IgM antibodies to M. pneumoniae were prospectively determined using the Meridian ImmunoCard Mycoplasma test in(More)
BACKGROUND The purpose of the present study was to evaluate associations of periodontal status with general health conditions and with serum antibody titers for Porphyromonas gingivalis (Pg) and Actinobacillus actinomycetemcomitans (Aa) in a Japanese population. METHODS Subjects (1,314) aged 40 years or older were recruited for the study. Their(More)
AIM To prospectively study how dental status with and without dentures could become a predictor of overall mortality risk. METHODS Five thousand six hundred eighty-eight community residents over 40 years old in the Miyako Islands, Okinawa Prefecture, Japan, were followed up for 15 years from 1987-2002. RESULTS We found that female subjects with less(More)