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- Yutaka Seino, Kishio Nanjo, +10 authors Kohjiro Ueki
- Journal of diabetes investigation
- 2010
CONCEPT OF DIABETES MELLITUS
Diabetes mellitus is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin… (More)
- Shinji Kume, Takashi Uzu, +7 authors Daisuke Koya
- The Journal of clinical investigation
- 2010
Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies demonstrate that this process is attenuated by calorie restriction (CR). However, the molecular mechanism that… (More)
- Keiji Isshiki, Masakazu Haneda, Daisuke Koya, Shin Maeda, Tsuneaki Sugimoto, Ryuichi Kikkawa
- Diabetes
- 2000
Thiazolidinedione (TZD) compounds are widely used as oral hypoglycemic agents. Herein, we provide evidence showing that troglitazone, one of the TZD compounds, is able to prevent glomerular… (More)
- Kunio Hirata, Shinji Kume, +9 authors Takashi Uzu
- Biochemical and biophysical research…
- 2009
The improvement of salt-sensitive hypertension is a therapeutic target for various vascular diseases. Glucagon-like peptide 1 (GLP-1), an incretin peptide, has been reported to have natriuretic… (More)
- Munehiro Kitada, Daisuke Koya, +4 authors Masakazu Haneda
- Diabetes
- 2003
Oxidative stress is implicated to play an important role in the development of diabetic vascular complications, including diabetic nephropathy. It is unclear whether oxidative stress is primarily… (More)
- Naoko Deji, Shinji Kume, +9 authors Takashi Uzu
- American journal of physiology. Renal physiology
- 2009
Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear. Although feeding of a high-fat diet (HFD) to C57BL/6 mice is reported to induce… (More)
- Shiro Yokohama, Masashi Yoneda, +7 authors Kimihide Nakamura
- Hepatology
- 2004
The therapeutic efficacy of angiotensin II receptor antagonist, losartan, was studied in patients with nonalcoholic steatohepatitis (NASH). Seven patients with both NASH and hypertension were treated… (More)
- Yukihiro Fujita, Rhonda D. Wideman, +5 authors Timothy J Kieffer
- American journal of physiology. Endocrinology and…
- 2009
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are released during meals from endocrine cells located in the gut mucosa and stimulate insulin secretion from… (More)
- Yuki Tanaka, Shinji Kume, +9 authors Takashi Uzu
- Kidney international
- 2011
As renal lipotoxicity can lead to chronic kidney disease (CKD), we examined the role of peroxisome proliferator-activated receptor (PPAR)-α, a positive regulator of renal lipolysis. Feeding mice a… (More)
- Eiichi Imai, Juliana C. N. Chan, +4 authors Hirofumi Makino
- Diabetologia
- 2011
The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an angiotensin… (More)