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Macrothrombocytopenia with leukocyte inclusions is a rare autosomal dominant platelet disorder characterized by a triad of giant platelets, thrombocytopenia, and characteristic Döhle body-like leukocyte inclusions. A previous study mapped a locus for the disease on chromosome 22q12.3-q13.2 by genome-wide linkage analysis. In addition, the complete DNA(More)
The in vitro effects of methotrexate (MTX) on cell cycle progression and DNA synthesis of L1210 leukemia cells were studied by the bromodeoxyuridine (BrdUrd)/DNA analysis technique. Low dose (10(-8) M) MTX, which slightly inhibits clonal replication of the cells, delays progress across the S phase, and treatment for 24 h results in a slight increase of the(More)
BACKGROUND Reports of non-anaplastic peripheral T-cell lymphoma (PTCL) in pediatric patients are relatively rare. PROCEDURE We performed a retrospective analysis in patients with PTCL over an 18-year period (1991-2008). RESULTS We could analyze clinical data in 21 patients with non-anaplastic PTCL; 10 were female and 10 male. Median age of onset was 11(More)
BACKGROUND Previous Japanese studies of childhood B-cell non-Hodgkin lymphoma (B-NHL) have shown a favorable outcome, though the study size was too small to effectively assess the efficacy and safety of treatment for childhood B-NHL. PROCEDURE We performed a nation-wide prospective B-NHL03 study to assess the efficacy and safety of short-pulse intensive(More)
T-cell acute lymphoblastic leukaemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are combined into one category as T lymphoblastic leukaemia/lymphoma in the current World Health Organization (WHO) classification. However, there is still ongoing discussion on whether T-ALL and T-LBL are two separate entities or represent two variant phenotypes of the(More)
Mouse abdominal wall-conditioned medium contains a factor which stimulated granulocyte-monocyte colony formation. To elucidate the role of colony-stimulating factor and the stromal microenvironment in long-term bone marrow cultures, effects of the conditioned medium on granulopoiesis were studied. Addition of the conditioned medium to the culture stimulated(More)
Colony promoting activity (CPA) was detected in the supernatants of the bone marrow cell cultures. CPA itself had no granulocyte-macrophage colony stimulating activity (CSF); but did increase the number and the size of colonies induced by the optimal dose of CSF. This activity was dose dependent and not specific to CSF sources. CPA-responsive cells (target(More)
BACKGROUND Long-course prednisolone regimens have been shown to be more effective than short-course regimens in sustaining remission of nephrotic syndrome in children. However, the most beneficial approach among the long-course regimens remains unknown. METHODS Seventy-three children with new-onset nephrotic syndrome were allocated at random to the two(More)
To investigate how chemotherapy agents interact with the leukemic cell death pathway, we examined apoptosis of human lymphoblastic leukemia cells (Nalm-6 and Molt-4) treated with various anticancer drugs (etoposide (VP-16), camptothecin (CPT), adriamycin (ADR), cytosine arabinoside (Ara-C), methotrexate (MTX), 6 mercaptopurine (6MP), cyclophosphamide (CPM),(More)