Masahisa Inoue

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The Long Evans Cinnamon (LEC) rat spontaneously develops fulminant hepatitis, which is usually lethal due to excess copper accumulation in the liver and is considered an animal model of Wilson's disease. LEC rats show a strong appetite for proline solution. Daily oral (p.o.) administration of proline resulted in significant delay of mortality. Feeding a(More)
As a test for specific hunger for amino acids with the goal of identifying brain regions which might mediate motivation to alleviate L-lysine (Lys) deficiency, rats were trained to lever press to receive complete diet. Rats were given Lys deficient (Lys-def) diet ad lib. Intraperitoneal (IP) injection of Lys, 2 h before the test session, inhibited lever(More)
Arsenic-induced toxicity appears to be dependent on the tissue- or cell-specific accumulation of this metalloid. An early study showed that arsenic was retained in the esophagus as well as the liver, kidney cortex and skin of marmosets after intraperitoneal administration of 74As-arsenite. However, there is little available information regarding the(More)
Rats were trained to maintain a high rate of bar pressing to receive 50-mg pellets of a complete diet when given a lysine-deficient (Lys-def) diet ad libitum. This bar-pressing behavior was significantly inhibited when rats were also allowed ad libitum access to 0.4 M Lys to drink. A brain activin system may modulate motivation to engage in bar-pressing(More)
The effect of continuous L-lysine (Lys) infusion on dietary choice between Lys deficient and protein-free diets in Sprague-Dawley rats was studied to determine the sensing site of Lys deficiency. After daily intake of each diet became constant, Lys was continuously infused for 11 days via intraperitoneal (IP), intragastric (IG) or intracerebroventricular(More)
To identify brain mechanisms which mediate hunger for amino acid (e.g. L-lysine; Lys) deficiency, rats were trained to bar press (FR30 schedule) to receive 50 mg pellets of a complete diet. Rats given a lysine deficient (Lys-def) diet ad libitum maintained a high rate of bar pressing but when allowed ad libitum access to 0.4 M Lys to drink had a significant(More)
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