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Species-dependent variations of myocardial alpha 1-adrenoceptor-mediated positive inotropic effects of epinephrine were assessed in relation to characteristics of alpha 1-receptor bindings and(More)
Experiments were carried out to study the effects of denopamine on myocardial alpha-1 adrenoceptors in the rabbit and on intracellular Ca++ transients in the dog ventricular muscle. Denopamine(More)
The influence of protein kinase C (PKC) inhibitors, staurosporine, NA 0345 and H-7, on the alpha 1- and beta-adrenoceptor-mediated positive inotropic effect (PIE) was studied in rabbit ventricular(More)
Endothelin-3 (ET-3), an isopeptide of ET, had a concentration-dependent positive inotropic effect (PIE) on rabbit papillary muscle. The maximal inotropic response to ET-3 was 65% of the maximal(More)
An adenosine A1 receptor agonist R-N6-phenylisopropyladenosine (R-PIA) elicited a pronounced negative inotropic effect with the EC50 value of 0.69 μmol/1 in the presence of a β-adrenoceptor blocking(More)
Species-dependent variations of myocardial ca1-adrenoceptor-mediated positive inotropic effects of epinephrine were assessed in relation to characteristics of ael-receptor bindings and acceleration(More)