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BACKGROUND MicroRNAs (miRNAs) are critical regulators of transcriptional and post-transcriptional gene silencing, which are involved in multiple developmental processes in many organisms. Apart from miRNAs, mouse germ cells express another type of small RNA, piwi-interacting RNAs (piRNAs). Although it has been clear that piRNAs play a role in repression of(More)
BACKGROUND To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked all microRNAs. PRINCIPAL FINDINGS Dicer-null NS cells underwent normal self-renewal and could be(More)
Imprinted genes are expressed in a parent-of-origin manner and are located in clusters throughout the genome. Aberrations in the expression of imprinted genes on human Chromosome 7 have been suggested to play a role in the etiologies of Russell-Silver Syndrome and autism. We describe the imprinting of KLF14, an intronless member of the Krüppel-like family(More)
BACKGROUND Argonaute2 protein (Ago2) is a key component of RNA-induced gene silencing complex, which is crucial for microRNA-mediated repression of target genes. The function of Ago2 in the mouse oocyte and early embryonic development is less well characterized but it is likely to have an important role in regulating maternally inherited mRNA. We have(More)
— This paper studies the energy based control for swinging up two pendulums on a cart. This paper presents an original and detail analysis of the convergence of the energies of two pendulums and provides the condition such that the pendulums can be swung up. Moreover, the stability analysis of the motion of two pendulums under the energy based control is(More)
Dynamic modeling for planar extensible continuum robot manipulators, " in Proc. IEEE Int. Conf. Abstract—This paper concerns a swing-up control problem for a three-link gymnastic planar robot in a vertical plane with its first joint being passive (unactuated) and the rest being active (actuated). The objectives of this paper are to: 1) design a controller(More)
[4] H. Kesten, " Random difference equations and renewal theory for products of random matrices, " Acta. , " Anytime capacity and a separation theorem for tracking unstable processes, " in Proc. Abstract—This note studies the posture control problem of a two-link free flying Acrobot with nonzero initial angular momentum, where the control objective is to(More)
BACKGROUND DNA methylation of cytosine residues in CpG dinucleotide controls gene expression and dramatically changes during development. Its pattern is disrupted in cloned animals suggesting incomplete reprogramming during somatic cell nuclear transfer (the first reprogramming). However, the second reprogramming occurs in the germ cells and epigenetic(More)
A 47-year-old woman developed intermittent shooting pain around the right side of the nose and eyes. A neurologist initially diagnosed trigeminal neuralgia, but carbamazepine did not improve the pain. Two months later, she presented with a pus-like eye discharge and was referred to us for further examination. Poor saline irrigation from the lacrimal puncta(More)