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Wikipedia, a huge scale Web based encyclopedia, attracts great attention as an invaluable corpus for knowledge extraction because it has various impressive characteristics such as a huge number of articles, live updates, a dense link structure, brief anchor texts and URL identification for concepts. We have already proved that we can use Wikipedia to(More)
Wikipedia, a collaborative Wiki-based encyclopedia, has become a huge phenomenon among Internet users. It covers a huge number of concepts of various fields such as Arts, Geography, History, Science, Sports and Games. As a corpus for knowledge extraction, Wikipedia's impressive characteristics are not limited to the scale, but also include the dense link(More)
BACKGROUND Duplications involving the methyl-CpG-binding protein 2 gene (MECP2) locus at Xq28 have been frequently identified in male patients who exhibit a phenotype unique from that of Rett syndrome, which is mainly characterized by severe mental retardation, recurrent infections, and epilepsy. This combination of features is recognized as MECP2(More)
Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na(+) to enter and be used as substrate for cation/proton antiporters responsible for cytoplasmic pH homeostasis. Here, we describe a new member of the prokaryotic voltage-gated(More)
The aim of the present study is to clarify whether physiological stimulation of vagal afferents modulates the activity of the trigeminal spinal nucleus oralis (TSNO) neurons related to the tooth-pulp (TP)-evoked jaw-opening reflex (JOR) in pentobarbital-anesthetized rats. The activity of TSNO neurons and the amplitude of digastric electromyogram (dEMG)(More)
The prokaryotic voltage-gated Na(+) channel, NaChBac, is one of a growing channel superfamily of unknown function. Here we show that Na(V)BP, the NaChBac homologue encoded by ncbA in alkaliphilic Bacillus pseudofirmus OF4, is a voltage-gated Na(+) channel potentiated by alkaline pH. Na(V)BP has roles in motility, chemotaxis, and pH homeostasis at high pH.(More)
O-glycosylation of mammalian proteins is one of the important posttranslational modifications. We applied a support vector machine (SVM) to predict whether Ser or Thr is glycosylated, in order to elucidate the O-glycosylation mechanism. O-glycosylated sites were often found clustered along the sequence, whereas other sites were located sporadically.(More)
It is important to enhance and detect nodules in CT images in order to identify the lung cancer at early stage. Nodules which are included in medical image generally have multiple size and scale, and have blob-like structure. Recently, 3D multiscale filter approach is proposed for lung nodules detection. However, the 3D method take too much computing time(More)