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BACKGROUND Apoptosis is reported to play an important role in left ventricular (LV) remodeling after acute myocardial infarction (AMI). Granzyme B is a member of the serine esterase family, which has an important role in cellular apoptosis and extracellular matrix degradation. METHODS AND RESULTS Peripheral blood samples were obtained from 33 patients(More)
The World Health Report 2000 placed Japan first for overall health system attainment: a surprising development considering that, aside from discussing excessive expenditure, health care professionals and the Health Ministry have paid little attention recently to the quality of health care. Japan's free access policy and the universal health care system have(More)
Osteopontin (OPN) has been described as playing a nonredundant role in renal crystal formation. Here we investigated the effects of impaired domains of OPN, namely, the Arg-Gly-Asp (RGD) sequence and two calcium-binding sites on crystal formation. We used wild-type mice (WT group), OPN knockout mice (KO group), and OPN knockout mice carrying either a(More)
OBJECTIVE We examined the relationship between hospital structural characteristics and system-level activities for patient safety and infection control, for use in designing an incentive structure to promote patient safety. METHODS This study utilized a questionnaire to collect institutional data about hospital infrastructure and volume of patient safety(More)
A 52-year-old woman with Takayasu arteritis developed acute coronary syndrome and received percutaneous coronary intervention (PCI). The patient experienced restenosis three times even with drug-eluting stent (DES) implantation. We started steroid administration after the fourth PCI to reduce inflammation due to autoimmunity. With DES and a steroid(More)
BACKGROUND Although currently available evidence predominantly recommends early laparoscopic cholecystectomy (LC) for the treatment of acute cholecystitis, this strategy has not been widely adopted in Japan. Herein, we describe a hospital-based study of patients with acute cholecystitis in 9 Japanese teaching hospitals in order to evaluate the impact of(More)
OBJECTIVE Under the fee-for-service system, the overuse and misuse of perioperative antibiotics have become serious concerns in Japan. The objective of the present study is to investigate practice variations of perioperative antimicrobial prophylaxis between and within hospitals, and to identify any opportunities for improvement. METHODS We polled 319(More)
OBJECTIVE We assessed variations in the use of breast conserving surgery (BCS) for operable breast cancer paticnts among hospitals in Japan, and then compared the length of stay (LOS) and total charges during hospitalization between patients who received BCS and those who received mastectomy. SETTING AND STUDY PARTICIPANTS We used a database from the(More)
BACKGROUND Delays and underreporting limit the success of hospital incident reporting systems, but little is known about the causes or implications of delayed reporting. SETTING AND METHODS The authors examined 6880 incident reports filed by physicians and nurses for three years at a national university hospital in Japan and evaluated the lag time between(More)
Recent clinical studies have revealed that the expression of endoglin, an accessory protein for the TGF-β receptor, is increased in patients with atherosclerotic diseases. The plasma endoglin level is thought to represent endothelial activation, inflammation, and senescence. To clarify the significance of plasma endoglin in chronic coronary artery disease.(More)