Masahiro Higuchi

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Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases

Masahiro Higuchi, Toshie Honda, Rita J. Proske, E. Yeh
Oncogene
1998

Reactive oxygen species (ROS) and caspases have been implicated as potential mediators of cell death. However, their mechanistic relationship remains to be elucidated. Here we investigated the roles… (More)

Regulation of mitochondrial DNA content and cancer.

Masahiro Higuchi
Mitochondrion
2007

Enzymatic activities of the proteins encoded in nuclear genome are regulated by transcriptional, translational and post-transcriptional level. Enzymatic activities of proteins encoded in… (More)

Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage.

Hiroko P. Indo, Mercy M. Davidson, +7 authors Hideyuki Majima
Mitochondrion
2007

Mitochondrial damage is a well known cause of mitochondria-related diseases. A major mechanism underlying the development of mitochondria-related diseases is thought to be an increase in… (More)

Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-Hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells

Seigo Suzuki, Masahiro Higuchi, Rita J. Proske, Nobuhiko Oridate, Waun Ki Hong, Reuben Lotan
Oncogene
1999

N-(4-Hydroxyphenyl)retinamide (4HPR) is currently used in cancer prevention and therapy trials. It is thought that its effects result from induction of apoptosis. 4HPR-induced apoptosis in human… (More)

Mitochondrial dysfunction induced by sertraline, an antidepressant agent.

Yan Li, Letha H Couch, Masahiro Higuchi, J L Fang, Lei Guo
Toxicological sciences : an official journal of…
2012

Sertraline, a selective serotonin reuptake inhibitor, has been used for the treatment of depression. Although it is generally considered safe, cases of sertraline-associated liver injury have been… (More)

Characterization of a novel plasma membrane protein, expressed in the midgut epithelia of Bombyx mori, that binds to Cry1A toxins.

Delwar Hossain, Yasuyuki Shitomi, +5 authors Hidetaka Hori
Applied and environmental microbiology
2004

We describe the properties of a novel 252-kDa protein (P252) isolated from brush border membranes of Bombyx mori. P252 was found in a Triton X-100-soluble brush border membrane vesicle fraction,… (More)

Structural control of peptide-coated gold nanoparticle assemblies by the conformational transition of surface peptides.

Masahiro Higuchi, Kae Ushiba, Masami Kawaguchi
Journal of colloid and interface science
2007

Gold nanoparticles having peptide chains on the surfaces have been prepared yb ring-opening polymerization of gamma-methyl L-glutamate N-carboxyanhydride with fixed amino groups on the nanoparticle… (More)

Artificial extracellular matrix proteins containing phenylalanine analogues biosynthesized in bacteria using T7 expression system and the PEGylation.

Akinori Takasu, Shiori Kondo, +4 authors Inchan Kwon
Biomacromolecules
2011

In vivo incorporation of phenylalanine (Phe) analogues into an artificial extracellular matrix protein (aECM-CS5-ELF) was accomplished using a bacterial expression host that harbors the mutant… (More)

Mitochondrial regulation of cancer associated nuclear DNA methylation.

Cheng-hui Xie, Akihiro Naito, +5 authors Masahiro Higuchi
Biochemical and biophysical research…
2007

The onset and progression of cancer is associated with the methylation-dependent silencing of specific genes, however, the mechanism and its regulation have not been established. We previously… (More)

The awakening of an advanced malignant cancer: an insult to the mitochondrial genome.

Cody C Cook, Masahiro Higuchi
Biochimica et biophysica acta
2012

BACKGROUND In only months-to-years a primary cancer can progress to an advanced phenotype that is metastatic and resistant to clinical treatments. As early as the 1900s, it was discovered that the… (More)

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