Masahiko Taguchi

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BACKGROUND Prognostic implications of overexpression of the HER-2 gene in nonsmall cell lung carcinoma (NSCLC) are a matter of controversy. Many conflicting results have been reported from different laboratories. METHODS A metaanalysis of published studies was performed for this quantitative review of the effects of HER-2 overexpression on survival among(More)
STUDY OBJECTIVE The aim of this study was to clarify whether fluorescence in situ hybridization (FISH) can diagnose lung cancer in various clinical specimens in comparison with conventional cytology. DESIGN Prospective study. SETTING University hospital in a metropolitan area. PATIENTS Fifty consecutive patients with abnormal chest radiography or CT(More)
Neurinomas originating from intercostal nerve roots can grow both inside and outside of the spinal canal, forming dumbbell-shaped tumors. Such a neurinoma was discovered at the Th3 and Th4 levels in a 73-year-old woman during evaluation for breast cancer surgery. Magnetic resonance images (MRI) showed spinal cord compression by the tumor despite lack of(More)
BACKGROUND Epidermal growth factor receptor (EGFR) gene mutations are frequently found in pulmonary adenocarcinomas. MATERIALS AND METHODS Various lung cancers (n=30) including 8 small adenocarcinomas were examined for EGFR gene mutations in three exons. RESULTS Mutations were detected in 32% of adenocarcinomas. Exon 19 mutations were detected in 5(More)
Immune cell migration into and through mucosal barrier sites in general and airway sites in particular is a critical feature of immune and inflammatory responses, but the determinants of transepithelial (unlike transendothelial) immune cell traffic are poorly defined. Accordingly, we used primary culture airway epithelial cells and peripheral blood(More)
A retrospective study of limited resection for lung cancer in a large number of patients was first reported in the 1970s. The reported outcome of segmentectomy was comparable to that of standard lobectomy. The North American Lung Cancer Study Group (LCSG) performed a randomized controlled clinical trial to compare limited resection (segment or wedge) with(More)
A 74-year-old man presented to our hospital with persistent low-grade back pain that had continued for 6 months. An expansile tumor containing delicate bony trabeculae was found in the posterior portion of the left fifth rib. Preoperative examination of a percutaneous needle biopsy specimen suggested a diagnosis of hemangioma; postoperative pathology(More)
We encountered a patient with three left lower lobe pulmonary tumors evident as discrete ground-glass opacities by computed tomography. Pathological diagnoses of the resected lesions included a focus of atypical adenomatous hyperplasia (AAH) and two localized noninvasive bronchioloalveolar carcinomas (BACs) of types A and C according to Noguchi's(More)
We describe our successful operative management of a solitary metastasis in the sternal body after modified left mastectomy. Because the primary lesion was well controlled and the sternal metastasis was isolated, we performed a subtotal sternectomy, with full-thickness resection of the anterior chest wall, including the sternal body and inferior part of the(More)
A minute small-cell lung cancer measuring 8 x 5 mm was detected and serially imaged by computed tomography for about a year preceding resection. Although this solid nodule showed a short overall doubling time (76 days), the growth curve included an early phase without apparent growth prior to the phase of rapid growth. Accordingly, lung cancer cannot be(More)