Masahi Kato

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Angiogenesis is not only dependent on endothelial cell invasion and proliferation, it also requires pericyte coverage of vascular sprouts for stabilization of vascular walls. Clinical efficacy of angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway is still limited to date. We hypothesized that the level of(More)
491 Angiogenesis is a pivotal process for growth, invasion, and spread of tumors and is therefore used as a therapeutic target in many types of cancer (Hanahan and Folkman, 1996; Ferrara and Kerbel, 2005). Sprouting of capillaries from preexisting blood vessels is accomplished by a hypoxia-driven mechanism, within which vas-cular endothelial growth factor(More)
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