Masafumi Yanagihara

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In this study, we examined the temporal and regional patterns of Smad activation in the rat hippocampus following global ischemia. We also examined the association between Smad activation and ischemia-induced pathology in the hippocampus. We found that 1) Smad1, -2, -3, and -5 proteins were detected in the rat hippocampus by means of western blot and(More)
The Wisconsin card sorting test (WCST) comprehensively examines executive function (EF). The Keio version of the WCST (KWCST) uses fewer cards and presents them in two steps, separated by a short pause during which an instruction is given. Being of short duration, this test is suitable for children with pervasive developmental disorder (PDD) and(More)
The cases with attention deficit/hyperactivity disorder (AD/HD) are known to have difficulties in performing various neuropsychological tests related to the executive function. Among them, the Wisconsin Card Sorting Test (WCST) is already applied to many children with AD/HD. There are, however, differences in the measurement of WCST, and also in the(More)
Continuous Performance Test (CPT) is widely used to assess the attention function and response inhibition in both children and adults. This study attempts to examine the performances of boys with attention deficit/hyperactivity disorder (AD/HD) and pervasive developmental disorder (PDD) with and without comorbid AD/HD using a CPT. Among the various versions(More)
The Kiddie Continuous Performance Test (K-CPT) was produced by Conners for children in age from 4 to 5 years. This study attempted to examine the developmental changes and gender differences of this test in children from preschool to adolescence, to verify its appropriate age range for application, and also to obtain a norm for clinical applications. K-CPT(More)
The Stroop test has been already applied to many children with attention deficit/hyperactivity disorder (AD/HD). There are, however, differences in the measurement of the Stroop test, and also in the background conditions of the patients, such as the status of comorbidity with learning disorder (LD), medication and the level of Intelligence Quotient (IQ),(More)
The Stroop test was originally invented by Stroop to measure selective attention and cognitive flexibility and various versions of this test have been developed by many other researchers. Since the Stroop test requires the examinee's sustained efforts, it is not readily applicable to children with developmental disorders. In order to overcome this weakness,(More)
The Wisconsin card sorting test (WCST) is applied to various types of neurological disorders. Since WCST requires the examinee's sustained efforts, it is not readily applicable to children with developmental disorders. In order to overcome this weakness, Keio version WCST (KWCST) was developed by reducing the number of cards from 128 to 48 and presenting(More)
P 300 event-related potentials were recorded in 72 normal subjects ranging from 5 to 25 years of age for three visual discrimination tasks. A progressive decrease of P300 latency with curvelinear function was found in all the tasks. However, the age/P300 latency slope from 5 to 14 years was different for two word discrimination tasks and a color(More)
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