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Role of Ahch in gonadal development and gametogenesis
TLDR
Although Ahch has been postulated to function as an ovarian determination gene, the loss of Ahch function in females does not affect ovarian development or fertility, and it is instead essential for the maintenance of spermatogenesis. Expand
Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells.
TLDR
Ectopic miR-34a expression resulted in cell cycle arrest and growth inhibition and attenuated chemoresistance to anticancer drug camptothecin by inducing apoptosis, suggesting a potential role of miR -34a for the treatment of p53-defective prostate cancer. Expand
An estrogen receptor (ER)alpha deoxyribonucleic acid-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo.
TLDR
A nonclassical estrogen receptor (ER) knock-in mouse model is created by introducing a mutation that selectively eliminates classical ER signaling through estrogen response elements, while preserving the non classical ER pathway, suggesting that nonclassicals ER signaling pathways play an important physiological role in the development and function of the reproductive system. Expand
Developmental and species-divergent globin switching are driven by BCL11A
TLDR
It is shown that alterations in the expression of a trans-acting factor constitute a critical driver of gene expression changes during evolution, and BCL11A is a critical mediator of species-divergent globin switching. Expand
Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner.
TLDR
In an infant with a similar clinical phenotype, an SF-1 mutation (R92Q) in a highly conserved residue of the A-box, a region that functions as a secondary DNA-binding domain is identified, revealing the relative functional importance of the P-box and A-boxes for monomeric binding by nuclear receptors. Expand
HIV-1 nef suppression by virally encoded microRNA
TLDR
The data suggest that nef/U3 miRNAs produced in HIV-1-infected cells may suppress both Nef function and HIV- 1 virulence through the RNAi pathway. Expand
Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1
TLDR
In in vitro transfection studies, aromatase seems to be a physiologic target of Dax-1 in Leydig cells, and increased Cyp19 expression may account, in part, for the infertility and LCH in Dax1-deficient mice. Expand
MiR‐34a attenuates paclitaxel‐resistance of hormone‐refractory prostate cancer PC3 cells through direct and indirect mechanisms
TLDR
This work aimed to elucidate the molecular mechanisms underlying paclitaxel resistance of hormone‐refractory prostate cancer with a special focus on the roles of miR‐34a and SIRT1. Expand
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
TLDR
Whether GDF‐15 is a more useful biomarker for MDs than several conventional biomarkers is investigated. Expand
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