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  • Davide Serruto, Matthew J Bottomley, Sanjay Ram, Marzia Monica Giuliani, Rino Rappuoli
  • Biology, Medicine
  • Vaccine
  • 2012 (First Publication: 1 May 2012)
  • Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and devastating septicemia. Although effective vaccines exist for several serogroups of pathogenic N.Continue Reading
  • Davide Serruto, Tiziana Spadafina, +20 authors Beatrice Aricó
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2010 (First Publication: 23 February 2010)
  • GNA2132 is a Neisseria meningitidis antigen of unknown function, discovered by reverse vaccinology, which has been shown to induce bactericidal antibodies in animal models. Here we show that thisContinue Reading
  • John J. Donnelly, Duccio Medini, +17 authors Marzia Monica Giuliani
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2010 (First Publication: 9 November 2010)
  • A unique multicomponent vaccine against serogroup B meningococci incorporates the novel genome-derived proteins fHbp, NHBA, and NadA that may vary in sequence and level of expression. Measuring theContinue Reading
  • Anja Seubert, Samuele Calabro, +13 authors Ennio de Gregorio
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2011 (First Publication: 5 July 2011)
  • Oil-in-water emulsions have been successfully used to increase the efficacy, immunogenicity, and cross-protection of human vaccines; however, their mechanism of action is still largely unknown. Nlrp3Continue Reading
  • Germano Ferrari, Ignazio Garaguso, +8 authors Guido Grandi
  • Biology, Medicine
  • Proteomics
  • 2006 (First Publication: 1 March 2006)
  • We compared the proteome of detergent-derived group B Neisseria meningitidis (MenB) outer membrane vesicles (DOMVs) with the proteome of outer membrane vesicles (m-OMVs) spontaneously released intoContinue Reading