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Journals and Conferences
The human interferon γ receptor (IFNGR1) gene has been localized by in situ hybridization to chromosome 6 at q23–q24. This chromosomal region is often deleted in lymphoid cell malignancies.
The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the… (More)
A novel dopamine D3 receptor gene that may be involved in psychiatric diseases has recently been characterized. It has been assigned to chromosome 3 by hybridization with a D3 receptor probe to human sorted chromosomes, and localized to band 3q 13.3 by in situ hybridization.
Chromosomal translocations involving the human 12p13 band frequently affect the TEL gene, usually resulting in gene fusion between TEL and genes encoding proteins of various types. The most frequent 12p13 translocation is the t(12;21)(p13;q22), which recombines TEL with the AML1 gene on chromosome 21 and is frequently associated with deletion of the… (More)
The receptor with high affinity for immunoglobulin E (FcERI) is a key molecule in triggering the allergic reaction. It isα tetrameric complex of oneα subunit, oneβ subunit, and two disulfide-linkedγ subunits. This receptor is present exclusively on mast cells and basophils. Molecules identical to theγ subunit of FcεRI also formα cell surface complex with… (More)
The human homologue of the recently isolated myeloproliferative leukemia virus, a retrovirus that induces myeloproliferative disorder in mouse, has been mapped in man to chromosome band 1p34 by in situ hybridization.
The gene encoding nuclear RNA ribonucleoprotein G (hnRNP-G), a p43 glycoprotein, has been mapped to human chromosome 6, band p12, by radioactive in situ hybridization.
Abnormalities of the short arm of chromosome 12 frequently involve the TEL/ETV6 gene in acute leukemias. In two cases of T cell acute lymphoblastic leukemia with translocation t(12;14)(p13;q11) and t(7;12)(q35;p13), respectively, the breakpoints were located telomeric to the TEL/ETV6 locus. Further fluorescence in situ hybridization (FISH) studies showed… (More)
Cytogenetic and fluorescence in situ hybridization studies have shown the presence of telomeric repeats in translocation present in three patients with hematopoietic malignancies. One had jumping translocations, involving 1q12 and 2q, 16p, and 19q. These sequences were detected by FISH only in derivative chromosomes t(1;16) and t(1;19) in the first patient,… (More)
Fusion genes implicating the MLL gene have been recently FH family members whose genes are already known to be demonstrated in various 11q23 chromosomal abnormalities involved in chromosomal translocations of human maligin human hematopoietic malignancies. We analyzed a nancies, AFX and FKHR. Strikingly, in these translocations t(6;11)(q21;q23)… (More)