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Genome-wide association studies have identified a linkage disequilibrium (LD) block on chromosome 12 associated with multiple sclerosis (MS), type 1 diabetes and other autoimmune diseases. This block contains CYP27B1, which catalyzes the conversion of 25 vitamin D3 (VitD3) to 1,25VitD3. Fine-mapping analysis has failed to identify which of the 17 genes in(More)
Genome-wide association studies have identified a linkage disequilibrium block on chromosome 12 associated with multiple sclerosis (MS), type 1 diabetes and other autoimmune diseases. This block contains CYP27B1, which catalyses conversion of 25 Vitamin D3 to 1,25 Vitamin D3. Fine mapping analysis has failed to identify which of the 17 genes in this block(More)
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