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BACKGROUND Vitamin D deficiency has long been suspected as a risk factor for glucose intolerance. This study compared serum levels of 25-hydroxy vitamin D(3) in pregnant women with gestational diabetes mellitus (GDM), impaired glucose tolerance (IGT), and non-GDM control subjects. METHODS In this case-control study, 54 women with diagnosed GDM and 39(More)
RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules. Whether and how RIPK3 might drive inflammation in a manner independent of MLKL and cell lysis remains unclear. Here we show that following LPS treatment, or LPS-induced necroptosis, the TLR adaptor protein(More)
AIM Adiponectin is an insulin sensitizing protein. Because gestational diabetes mellitus is associated with insulin resistance, we compared serum adiponectin levels in women with gestational diabetes mellitus and healthy pregnant women. STUDY DESIGN Twenty-nine women with gestational diabetes and 26 women with impaired glucose tolerance were compared with(More)
BACKGROUND Type 2 diabetes is a common disorder that is recognized as a major health problem in Iran. Diabetes is a major cause of morbidity, mortality, and economic burden to the society. Some people believe that smoking opium can reduce serum glucose and lipids in diabetes mellitus. This study was designed to compare blood glucose and lipids in opium(More)
OBJECTIVE Gestational diabetes mellitus (GDM) affects approximately 7% of all pregnancies. Pregnancy, mostly because of the mitochondria-rich placenta, is a condition that favors oxidative stress. A transitional metal, especially iron, which is particularly abundant in the placenta, is important in the production of free radicals. Also, studies have shown(More)
BACKGROUND This study was performed to assess the prevalence of dry eye syndrome and diabetic retinopathy (DR) in type 2 diabetic patients and their contributing factors. METHODS 199 type 2 diabetic patients referred to Yazd Diabetes Research Center were consecutively selected. All Subjects were assessed by questionnaire about other diseases and drugs.(More)
Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune disease: Pancreatic β-cell autoantigens are defined, at-risk individuals can be identified before the onset of symptoms, and autoimmune diabetes is preventable in rodent models. Intervention in asymptomatic individuals before or after the onset of subclinical islet(More)
OBJECTIVE The aim of this study was to evaluate fasting serum leptin concentration and its relation to insulin resistance in women with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (IGT). MATERIALS AND METHODS This case-control study, at 28 weeks of gestation, measured serum concentration of fasting leptin, insulin, and(More)
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OBJECTIVE To assess the incidence and trend of the metabolic syndrome phenotype in adolescents from the Tehran Lipid and Glucose Study during 3.6 years of follow-up. RESEARCH DESIGN AND METHODS A total of 932 adolescents, aged 10-19 years, who had complete data and returned for reassessment 3.6 years later were investigated. RESULTS Prevalence of(More)