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The semisynthetic streptogramin combination quinupristin/dalfopristin (Synercid) is a promising alternative for treatment of infections due to multiply resistant gram-positive bacteria including vancomycin-resistant Enterococcus faecium. Resistance is mediated by acetyltransferases SatA (VatD) or SatG (VatE). Recent papers have indicated a possible link(More)
To investigate the prevalence of chlamydial infection and their significance for reproductive disorders in sow breeding herds in Germany, blood samples of 1493 pigs were taken for a serological survey by enzyme-linked-immunosorbent-assay (ELISA). Antibodies to Chlamydiae were found in 33% of the samples, in all herds investigated responders could be(More)
INTRODUCTION Toxicology and pharmacology studies conducted in the early stages of drug discovery often require formulation strategies involving the use of excipients with limited knowledge regarding their preclinical safety liabilities. The use of excipients is vital to efforts to solubilize and deliver small molecules in drug discovery. Whilst excipients(More)
The histology and ultrastructure of the urothelium lining the ureter and renal pelvis in sows was examined using light microscopy, and scanning and transmission electron microscopy. The epithelium of both the ureter and the renal pelvis were similar and consisted of the basal, the intermediate and the superficial cells. The luminal surface of the(More)
Necessity and facilities of clinical laboratory diagnostics in veterinary swine practice are discussed. The selection of suitable tests with regard to diagnostic relevance and reliability is pointed out. Typical test features (sensitivity and specificity) as well as disease dependent parameters (prevalence, positive or negative predictive value) are(More)
Comparative examinations of renal function using inulin- and endogenous creatinine-clearance tests in 5 pigs showed nearly identical values of glomerular filtration rate (GFR). Based on this relation 79 healthy pigs, weighting 2 kg to 230 kg were investigated using the creatinine-clearance test for determination of normal values of GFR and urine flow rate(More)
Morphological investigations of the urethra, urinary bladder (2 localizations), ureter, renal pelvis and kidneys were performed in sows with Corynebacterium suis infection. The first stages of the disease were characterized by changes of the transitional epithelium in the bladder where epithelial vacuolisation, goblet cell differentiation, leucocytic(More)
Tissues from ureter and renal pelvis of 18 sows naturally (n = 15) and experimentally (n = 3) infected with Actinobaculum suis (former Actinomyces, Eubacterium suis) were studied using light and scanning as well as transmission electron microscopy. The results were compared with the findings from 11 clinically healthy sows as controls. The lesions in both(More)
A light- and electron-microscope investigation was performed to examine the normal structure of the porcine urinary bladder. Tissue biopsies were studied obtained from 10 healthy female pigs (four weanling pigs, six sows). The bladder wall showed a typical stratification consisting of a tunica (t.) mucosae, t. submucosae, t. muscularis and t. serosa. The(More)