Mary Waltham

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committee's findings. Although the substance of the report is final, editorial changes may be made throughout the text prior to publication. The final report will be available through the National Academies Press later this year. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate(More)
Variants of dihydrofolate reductase (DHFR), which confer resistance to antifolates, are used as dominant selectable markers in vitro and in vivo and may be useful in the context of gene therapy. To identify improved mutant human DHFRs with increased catalytic efficiency and decreased binding to methotrexate, we constructed by site-directed mutagenesis four(More)
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