Mary Varughese

Learn More
BACKGROUND Anthrax toxin, secreted by Bacillus anthracis, consists of protective antigen (PA) and either lethal factor (LF) or edema factor (EF). PA, the receptor-binding component of the toxin, translocates LF or EF into the cytosol, where the latter proteins exert their toxic effects. We hypothesized that anthrax toxin fusion proteins could be used to(More)
Anthrax toxin from Bacillus anthracis is a three-component toxin consisting of lethal factor (LF), edema factor (EF), and protective antigen (PA). LF and EF are the catalytic components of the toxin, whereas PA is the receptor-binding component. To identify residues of PA that are involved in interaction with the cellular receptor, two solvent-exposed loops(More)
Piperine, the bioactive phytochemical from black pepper (Piper nigrum L.), is a nontoxic natural compound exhibiting many physiological and pharmacological properties. They include antioxidant, anti-inflammatory, antimutagenic, antitumor, antiapoptotic, antigenotoxic, antiarthritic, antifungal, antimicrobial, antidepressant, anti-HBV, and gastro-protective(More)
Context:This studycompares the clinical effectiveness of newly designed pulse oximetry probe over conventional technique of electric pulp testing and thermal testing. Aims:To evaluate the clinical efficacy of customized pulseoximeter probe over the conventional thermal and electrical testing of tooth vitality Settings and Design:The conventional pulse(More)
The leakage of bacteria through endodontic repair materials is a matter of great concern in dentistry, as the success of repair of furcation perforations or root ends lies in the seal provided by the material against bacterial infiltrations. In vitro microleakage techniques (like dye penetration and fluid filtration) are used to assess the sealing ability(More)
  • 1