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XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.
Using genome-wide approaches, we have elucidated the regulatory circuitry governed by the XBP1 transcription factor, a key effector of the mammalian unfolded protein response (UPR), in skeletalExpand
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An initial blueprint for myogenic differentiation.
We have combined genome-wide transcription factor binding and expression profiling to assemble a regulatory network controlling the myogenic differentiation program in mammalian cells. We identifiedExpand
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E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation.
Current models posit that E2F transcription factors can be divided into members that either activate or repress transcription, in part through collaboration with the retinoblastoma (pRb) tumorExpand
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Desmin related disease: a matter of cell survival failure.
Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic network that through interactions with all vital cell structures, provides an effective mechanochemicalExpand
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Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
Lung adenocarcinoma (LUAD)-derived Wnts increase cancer cell proliferative/stemness potential, but whether they impact the immune microenvironment is unknown. Here we show that LUAD cells useExpand
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Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival
ABSTRACT The association of desmin with the α-crystallin Β-chain (αΒ-crystallin; encoded by CRYAB), and the fact that mutations in either one of them leads to heart failure in humans and mice,Expand
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Traf7, a MyoD1 transcriptional target, regulates nuclear factor‐κB activity during myogenesis
We have identified the E3 ligase Traf7 as a direct MyoD1 target and show that cell cycle exit—an early event in muscle differentiation—is linked to decreased Traf7 expression. Depletion of Traf7Expand
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Intermediate filaments in cardiomyopathy
Intermediate filament (IF) proteins are critical regulators in health and disease. The discovery of hundreds of mutations in IF genes and posttranslational modifications has been linked to a plethoraExpand
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RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling
The activity of the E3 ligase, SMURF2, is antagonized by an intramolecular, autoinhibitory interaction between its C2 and Hect domains. Relief of SMURF2 autoinhibition is induced by TGFβ and isExpand
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