Mary Trang Le

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The public health consequences that are associated with the low level exposure of various human populations to Cd(2+) and Hg(2+) are incompletely understood. In order to assess if interactions between these inorganic pollutants and erythrocyte biomembranes may contribute to their chronic toxicity, we have used a Langmuir trough to probe the effect of HgCl2(More)
Biological membranes contain a multitude of lipids, proteins, and carbohydrates unique for any given cell or organism, and are a critical component of many biological processes. Animal and cell cultures have been used to understand these biological processes at the membrane level and more traditionally, to assess toxicity. However, the complex composition(More)
An ab-interno technique using a pigmented rabbit model has been developed that uses a pulsed erbium:YAG laser to create an iridotomy with a sclerostomy through the same corneal incision. Laser energy was delivered with an articulated arm terminating in side-firing (850 or 650 microns OD) or end-firing (850 or 400 microns OD) fiber optic endoprobes, which(More)
In order to characterize the potentially deleterious effects of toxic Hg2+ and Cd2+ on lipid membranes, we have studied their binding to liposomes whose composition mimicked erythrocyte membranes. Fluorescence spectroscopy utilizing the concentration dependent quenching of Phen Green™ SK by Hg2+ and Cd2+ was found to be a sensitive tool to probe these(More)
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