Mary P. Stenzel-Poore

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Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2

Sarah C. Coste, Robert A Kesterson, +14 authors Mary P. Stenzel-Poore
Nature Genetics
2000

The actions of corticotropin-releasing hormone (Crh), a mediator of endocrine and behavioural responses to stress, and the related hormone urocortin (Ucn) are coordinated by two receptors, Crhr1… (More)

Mechanisms of ischemic brain damage

Kristian P Doyle, Roger Simon, Mary P. Stenzel-Poore
Neuropharmacology
2008

In the United States stroke is the third leading cause of death and the leading cause of disability. Brain injury following stroke results from the complex interplay of multiple pathways including… (More)

Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states

Mary P. Stenzel-Poore, Susan L. Stevens, +9 authors Roger Simon
The Lancet
2003

BACKGROUND Molecular mechanisms of neuroprotection that lead to ischaemic tolerance are incompletely understood. Identification of genes involved in the process would provide insight into cell… (More)

Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice.

Mary P. Stenzel-Poore, Vicky A. Cameron, Joan Vaughan, Paul E Sawchenko, Wylie Vale
Endocrinology
1992

CRF is released in response to various stressors and regulates ACTH secretion and glucocorticoid production. CRF overproduction has been implicated in affective disorders, such as depression and… (More)

Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance.

H L Rosenzweig, Manabu Minami, +6 authors Mary P. Stenzel-Poore
Journal of cerebral blood flow and metabolism…
2007

Lipopolysaccharide (LPS) preconditioning provides neuroprotection against subsequent cerebral ischemic injury. Tumor necrosis factor-alpha (TNFalpha) is protective in LPS-induced preconditioning yet… (More)

LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury

Keri B. Vartanian, Susan L. Stevens, Brenda J. Marsh, Rebecca Williams-Karnesky, Nikola S Lessov, Mary P. Stenzel-Poore
Journal of Neuroinflammation
2011

Toll-like receptor 4 (TLR4) is activated in response to cerebral ischemia leading to substantial brain damage. In contrast, mild activation of TLR4 by preconditioning with low dose exposure to… (More)

Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3.

Cui Cui Chen, Mary P. Stenzel-Poore, Marvin B. Rittenberg
Journal of immunology
1991

We describe three sets of natural (preimmune) polyreactive antibodies and Ag-induced antibodies that share the same VH-VL combinations. The amino acid homology in the VH and VL segments averaged 92%.… (More)

Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury.

Susan L. Stevens, Philberta Y. Leung, +4 authors Mary P. Stenzel-Poore
The Journal of neuroscience : the official…
2011

Ischemic tolerance can be induced by numerous preconditioning stimuli, including various Toll-like receptor (TLR) ligands. We have shown previously that systemic administration of the TLR4 ligand LPS… (More)

Structural and functional conservation of vertebrate corticotropin-releasing factor genes: evidence for a critical role for a conserved cyclic AMP response element.

Meng Yao, Mary P. Stenzel-Poore, Robert J Denver
Endocrinology
2007

Corticotropin-releasing factor (CRF) plays a central role in neuroendocrine, autonomic, immune, and behavioral responses to stressors. We analyzed the proximal promoters of two Xenopus laevis CRF… (More)

Neuroprotection by osteopontin in stroke.

Robert Meller, Susan L. Stevens, +7 authors Mary P. Stenzel-Poore
Journal of cerebral blood flow and metabolism…
2005

Osteopontin (OPN) is a secreted extracellular phosphoprotein involved in diverse biologic functions, including inflammation, cell migration, and antiapoptotic processes. Here we investigate the… (More)

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