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We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r2 of between(More)
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a(More)
Recently, a number of single nucleotide polymorphisms (SNPs) were identified to be associated with late-onset Alzheimer disease (LOAD) through genome-wide association study data. Identification of SNP-SNP interaction played an important role in better understanding genetic basis of LOAD. In this study, fifty-eight SNPs were screened in a cohort of 229 LOAD(More)
Increasing evidence indicates that developmental dyslexia (DD) is a "disconnection syndrome", and new probes of connectome were applied to investigate the "disconnection" in DD. However, there is a lack of brain connectome studies of Chinese dyslexics, who may have a different neural impairment pattern due to the logographic nature of Chinese. The aim of(More)
INTRODUCTION Recent studies indicated that supplementation of phosphatidylcholine has been found to be beneficial for psychiatric diseases and Diacylglycerol Kinase, Eta (DGKH) protein was involved in regulating the metabolism of phosphatidic acid and diacylglycerol. This study reported a case of a 16-year-old Chinese boy with bipolar hypomania symptoms(More)
OBJECTIVE Animal evidence and genetic studies suggest that HOMER1 (homer homolog 1) is involved in the etiology of suicidal behavior and major depression disorder (MDD). However, most of genetic studies were performed in Caucasians and the potentially functional role of associated polymorphisms in HOMER1 was seldom reported. The purpose of this study was to(More)
Visual expertise in distinguishing words from objects and word-like stimuli is a fundamental skill that is important for children to become proficient readers. This expertise can be indexed by the N1 component of ERPs at the neural level. However, the nature of N1 tuning for print is controversial in terms of onset of the latency, lateralization and the(More)
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