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With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a(More)
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r2 of between(More)
Invited Paper Now that the human genome has been sequenced, the measurement , processing, and analysis of specific genomic information in real time are gaining considerable interest because of their importance to better the understanding of the inherent genomic function, the early diagnosis of disease, and the discovery of new drugs. Traditional methods to(More)
Developmental dyslexia, the most common childhood learning disorder, is highly heritable, and recent studies have identified KIAA0319-Like (KIAA0319L) as a candidate dyslexia susceptibility gene at the 1p36-34 (DYX8) locus. In this experiment, we investigated the anatomical effects of knocking down this gene during rat corticogenesis. Cortical progenitor(More)
Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from(More)
Increasing evidence indicates that developmental dyslexia (DD) is a "disconnection syndrome", and new probes of connectome were applied to investigate the "disconnection" in DD. However, there is a lack of brain connectome studies of Chinese dyslexics, who may have a different neural impairment pattern due to the logographic nature of Chinese. The aim of(More)
  • Jesús Pascual Mena-Chalco, Roberto Marcondes, Cesar-Jr, C Liew, H Yan, M Yang +12 others
  • 2005
An important topic in biological sequences analysis area is the protein coding regions identification. This identification allows the posterior research for meaning, description or biological cat-egorization of the analyzed organism [1]. Currently , several methods combine pattern recognition with knowledge collected from training datasets of known genes or(More)
Short hydrogen bonds and specifically low-barrier hydrogen bonds (LBHBs) have been the focus of much attention and controversy for their possible role in enzymatic catalysis. The green fluorescent protein (GFP) mutant S65T, H148D has been found to form a very short hydrogen bond between Asp148 and the chromophore resulting in significant spectral(More)
INTRODUCTION Recent studies indicated that supplementation of phosphatidylcholine has been found to be beneficial for psychiatric diseases and Diacylglycerol Kinase, Eta (DGKH) protein was involved in regulating the metabolism of phosphatidic acid and diacylglycerol. This study reported a case of a 16-year-old Chinese boy with bipolar hypomania symptoms(More)
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