Mary M O'connell

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Adolescents of many mammalian species exhibit rapid physiological change that is accompanied by behaviors such as increased risk taking and social interaction with peers. Marijuana abusers frequently report that their initial use occurred during adolescence. Our goal was to determine whether the in vivo effects of Delta(9)-tetrahydrocannabinol(More)
RATIONALE Individuals vary in their susceptibility to nicotine addiction. However, there is little evidence that behavioral sensitivity to nicotine is dependent upon the functional state of nicotinic cholinergic receptors (nAChRs). OBJECTIVE This study aims to determine the relationship between in vivo behavioral desensitization and in vitro(More)
OBJECTIVE To determine if combining standard drug concentrations with "smart-pump" technology reduces reported medication-infusion errors. DESIGN Preintervention and postintervention comparison of reported medication errors related to infusion therapies during the calendar years 2002 and 2003. SETTING A 242-bed university-affiliated tertiary pediatric(More)
In order to compare the effect of 3,5,3'-triiodothyroacetic acid (TRIAC) with those of triiodothyronine (T3) and thyroxine (T4), severely hypothyroid rats (n=56) were infused over 13 days with 1, 2 or 4 nmol/100 g body weight (BW) per day of T3 or 2, 4 or 8 nmol/100 g BW per day of T4 or TRIAC. The 8 nmol/100 g BW per day of T4 or TRIAC induced the same(More)
The Lewis (LEW) strain of rat appears more sensitive to nicotine than other strains in self-administration, conditioned place preference, and drug discrimination behavioral studies. The present study sought to further evaluate the behavioral effects of chronic nicotine treatment in the LEW strain by assessing spontaneous activity, which has consistently(More)
This study, conducted in 36 human volunteers, was an evaluation of the effects of saline iontophoresis on skin temperature, irritation, and barrier function. The major objectives were to assess the effects of low-level ionic currents, to validate the proposed methodology of assessment, and to establish reproducibility in repeated saline iontophoresis(More)
Glia maturation factor (GMF) was tested on separate cultures of glioblasts and fibroblasts isolated from the same rate fetuses. The astrocytic marker glial fibrillary acidic (GFA) protein and the fibroblast marker fibronectin were visualized with immunofluorescence. Before GMF stimulation, glioblasts showed only background fluorescence for GFA protein and(More)
The reported association between sarcoidosis and malignancy has relevance both to the diagnosis of the cause of lymphadenopathy and possibly also to the prognosis of the malignant disease. A case is reported in which mediastinal lymphadenopathy due to non-caseating epithelioid granulomata caused diagnostic difficulty in the staging investigation of a(More)
BACKGROUND Squamous cell carcinoma (SCC) of the tonsil is the most common malignant tumour of the oropharynx. Paediatric tonsillectomy is one of the most commonly performed procedures in Otorhinolaryngology. SCC of the tonsil remnant (SCCTR) in a previously tonsillectomised patient is rare. METHODS Retrospective review of patients with SCCTR presenting to(More)
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