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Human filarial nematodes cause river blindness and lymphatic filariasis, both of which are diseases that produce considerable morbidity. Control of these diseases relies on drug treatments that are ineffective against macrofilariae and are threatened by the development of resistance. New validated drug targets are required to allow development of new(More)
Executive Summary River blindness (onchocerciasis) and lymphatic filariasis, caused by infections with filarial nematodes, are important tropical diseases causing considerable morbidity, estimated at 951,000 DALYs for river blindness and 5.5 million DALYs for lymphatic filariasis. Control and treatment of these infections is difficult: no vaccines are(More)
Xenopus oocytes are versatile cells capable of carrying out many post-translational processes. Although previously reported not to be capable of C-terminal amidation, this report demonstrates that Xenopus oocytes do indeed have an amidating enzyme. The amidating activity from Xenopus ovaries is compared to the known amidating activity found in porcine(More)
HeLa cells were transfected with recombinant DNAs containing the embryonic histone gene repeat of P.miliaris (h22) inserted in either orientation into a pBR-SV40 vector. After 2 to 3 days cytoplasmic RNA was analyzed for authentic sea urchin histone gene transcripts. The correct 5' termini of all five histone genes were detected, three (H2B, H2A and H3) at(More)
In polyoma virus the origin of replication, the 5' ends of early mRNAs, and the initiation codon for early protein synthesis map within an approximately 200 bp region of the genome. We have previously reported the isolation and partial characterization of viable mutants of polyoma virus with deletions in this important regulatory region of the genome. Three(More)
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