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To further elucidate the incidence and potential mechanism sity or hyperglycemia. Apolipoprotein B 100 levels increased during asparaginase therapy, although the mechanism of of asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia (ALL), we serially ob-this remains unclear. LDL reciprocally decreased with increased VLDL(More)
Maximum likelihood estimation techniques for subject-specific (SS) generalized linear mixed models and generalized estimating equations for marginal or population-averaged (PA) models are often used for the analysis of cluster-unit intervention trials. Although both classes of procedures account for the presence of within-cluster correlations, the(More)
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