Mary Louise Torchiana

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MK-208 [3-(((2-(aminoiminomethyl)amino)-4-thiazolyl)-methyl)thio)-N'-(a minosulfonyl) propanimidamide], also known as YM-11170, is a highly potent histamine H2-receptor antagonist in guinea-pig atria, acting via a unique binding mechanism. Unlike ranitidine, the onset of action of this compound was slow and its inhibitory action was difficult to remove from(More)