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OBJECTIVE To describe the clinical and molecular genetic analysis of a large family of northern Chinese descent with a mutation at the SCA2 locus causing carbidopa-levodopa-responsive parkinsonism. BACKGROUND Most causes of parkinsonism remain unknown. However, molecular genetic analysis of families with parkinsonism has recently identified five distinct(More)
Filmed vignettes of socially stressful situations elicit changes in emotional states and physiological activation. Several studies have reported changes in mood and physiological activity in African Americans who encountered laboratory analogs of stressful situations. However, none have examined gender differences. African-American college students (52(More)
BACKGROUND Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), can present with parkinsonism. However, classically, atypical features, including pyramidal and cerebellar signs, peripheral neuropathy, and/or anterior horn cell dysfunction, are also seen. Levodopa responsiveness is unusual in this disorder. OBJECTIVE To(More)
PURPOSE Unresectable chest wall recurrences of breast cancer (CWR) in heavily pretreated patients are especially difficult to treat. We hypothesised that thermally enhanced drug delivery using low temperature liposomal doxorubicin (LTLD), given with mild local hyperthermia (MLHT), will be safe and effective in this population. PATIENTS AND METHODS This(More)
  • M I Adamovich, Yu A Alexandrov, D Barberis, M Beck, C B Erat, W Beusch +56 others
  • 1997
Inclusive cross sections for ? hyperon production in high-energy ? , ? and neutron induced interactions were measured by the experiment WA89 at CERN. Secondary ? and ? beams with average momenta of 345 GeV=c and a neutron beam of average momentum 65 GeV=c were produced by primary protons of 450 GeV=c from the CERN SPS. Both single and double diierential(More)
To confirm recent observations that some vitamin D deficient osteomalacic patients had low plasma creatinine concentrations, low urinary creatinine excretion, and a paradoxically low creatinine clearance, and whether these changes were due to vitamin D deficiency per se, these measurements were made in patients before and after vitamin D supplementation.(More)
We present a method for estimating the empirical dynamic treatment effect (DTE) curves from tumor growth delay (TGD) studies. This improves on current common methods of TGD analysis, such as T/C ratio and doubling times, by providing a more detailed treatment effect and overcomes their lack of reproducibility. The methodology doesn't presuppose any prior(More)
The appearance of Freud's earliest writings at the beginning of this century marked the birth of modern systematic and scientific psychotherapy. The following development was explosive in its depth and breadth. It was primarily the group psychotherapies that contributed most to the development in breadth. They practised the reverse of Freud's basic teaching(More)