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  • C Bond, Karl Steven Laforge, +10 authors Li-ying Yu
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 1998 (First Publication: 4 August 1998)
  • Opioid drugs play important roles in the clinical management of pain, as well as in the development and treatment of drug abuse. The mu opioid receptor is the primary site of action for the mostExpand
  • Rajita Sinha, Helen C. Fox, Kwang-ik Adam Hong, Julie Hansen, Keri L Tuit, Mary Jeanne Kreek
  • Psychology, Medicine
  • Archives of general psychiatry
  • 2011 (First Publication: 5 September 2011)
  • CONTEXT Alcoholism is a chronic, relapsing illness in which stress and alcohol cues contribute significantly to relapse risk. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, increasedExpand
  • Yong Zhang, Eduardo R Butelman, Stefan D. Schlussman, Ann Ho, Mary Jeanne Kreek
  • Psychology, Medicine
  • Psychopharmacology
  • 2004 (First Publication: 1 May 2005)
  • RationaleSalvinorin A is a naturally occurring hallucinogen derived from the plant Salvia divinorum. Salvinorin A is also a potent and selective kappa opioid receptor agonist in vitro. It has beenExpand
  • John R Mantsch, Vadim P Yuferov, Anne-Marie Mathieu-Kia, Ann Ho, Mary Jeanne Kreek
  • Psychology, Medicine
  • Psychopharmacology
  • 2004 (First Publication: 1 August 2004)
  • RationaleThe investigation of rodent cocaine self-administration (SA) under conditions that promote escalating patterns of intake may provide insight into the loss of control over drug use that isExpand
  • Stephanie S O'Malley, Suchitra Krishnan-Sarin, Conor Farren, Rajita Sinha, Mary Jeanne Kreek
  • Psychology, Medicine
  • Psychopharmacology
  • 2002 (First Publication: 1 February 2002)
  • Abstract.Background: This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of relapse to heavy drinking in individuals with alcoholExpand
  • Rajita Sinha, Miguel García, Prashni Paliwal, Mary Jeanne Kreek, Bruce J. Rounsaville
  • Psychology, Medicine
  • Archives of general psychiatry
  • 2006 (First Publication: 1 March 2006)
  • BACKGROUND Cocaine dependence is associated with high rates of relapse. Stress and drug cue exposure are known to increase cocaine craving and stress arousal, but the association between theseExpand
  • Johan Kakko, Kerstin Dybrandt Svanborg, Mary Jeanne Kreek, Markus Heilig
  • Medicine
  • The Lancet
  • 2003 (First Publication: 1 February 2003)
  • BACKGROUND The partial opiate-receptor agonist buprenorphine has been suggested for treatment of heroin dependence, but there are few long-term and placebo-controlled studies of its effectiveness. WeExpand