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Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs). We previously reported that histone hypercitrullination catalyzed by peptidylarginine deiminase 4 (PAD4) correlates with chromatin decondensation during NET formation. However, the role of PAD4 in NET-mediated bacterial(More)
  • Ujjawal H Gandhi, Naveen Kaushal, +6 authors K Sandeep Prabhu
  • 2014
Eradicating cancer stem-like cells (CSC) may be essential to fully eradicate cancer. Metabolic changes in CSC could hold a key to their targeting. Here, we report that the dietary micronutrient selenium can trigger apoptosis of CSC derived from chronic or acute myelogenous leukemias when administered at supraphysiologic but nontoxic doses. In leukemia CSC,(More)
Bordetellae are important respiratory pathogens that cause pertussis (whooping cough) in humans and analogous diseases in domestic and wild animals. Immunity to Bordetella is poorly understood, in particular the early innate immune responses that contribute to inflammation, pathology, and the subsequent generation of adaptive immunity. Using B.(More)
Peroxisome proliferator–activated receptor (PPAR) b/d–null mice exhibit exacerbated hepatotoxicity in response to administration of carbon tetrachloride (CCl 4). To determine whether ligand activation of the receptor protects against chemical toxicity in the liver, wild-type and PPARb/d-null mice were administered CCl 4 with or without coadministration of(More)
Type VI Secretion Systems (T6SSs) have been identified in numerous gram-negative pathogens, but the lack of a natural host infection model has limited analysis of T6SS contributions to infection and pathogenesis. Here, we describe disruption of a gene within locus encoding a putative T6SS in Bordetella bronchiseptica strain RB50, a respiratory pathogen that(More)
Ligand activation of peroxisome proliferator–activated receptor-b/d (PPARb/d) and inhibition of cyclooxygenase-2 (COX2) activity by nonsteroidal anti-inflammatory drugs (NSAID) can both attenuate skin tumorigenesis. The present study examined the hypothesis that combining ligand activation of PPARb/d with inhibition of COX2 activity will increase the(More)
Salmonella Enteritidis (SE) is one of the most common causes of bacterial food-borne illnesses in the world. Despite the SE's ability to colonize and infect a wide-range of host, the most common source of infection continues to be the consumption of contaminated shell eggs and egg-based products. To date, the role of the source of SE infection has not been(More)
The Type Six Secretion System (T6SS) is required for Bordetella bronchiseptica cytotoxicity, cytokine modulation, infection, and persistence. However, one-third of recently sequenced Bordetella bronchiseptica strains of the predominantly human-associated Complex IV have lost their T6SS through gene deletion or degradation. Since most human B. bronchiseptica(More)
Previous studies have demonstrated the ability of an eicosapentaenoic acid (EPA)-derived endogenous cyclopentenone prostaglandin (CyPG) metabolite, Δ(12)-PGJ3, to selectively target leukemic stem cells, but not the normal hematopoietic stems cells, in in vitro and in vivo models of chronic myelogenous leukemia (CML). Here we evaluated the stability,(More)
158 PERSPECTIVES fi xed in carbonate shells, can help researchers estimate where and how fast the conveyor has moved. Today, it appears that a deepwater parcel that forms in the North Atlantic will reach the southernmost Atlantic after about 1400 " 14 C years, " and reach the northeastern Pacifi c after more than 2200 14 C years; this is equivalent to a(More)
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