Mary Gottwald

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Impaired cellular coupling is thought to be a very important factor for the genesis of cardiac arrhythmia. Cellular coupling is mediated by gap junctions. However, there are no therapeutic agents or experimental substances yet that increase cellular coupling. In addition, it has been shown that most antiarrhythmic drugs available now possess serious adverse(More)
We investigated the effects of the antiarrhythmic peptide AAP10 (GAG-4Hyp-PY-CONH2, 50 nM) on pairs of adult guinea pig cardiomyocytes and on pairs of HeLa-cells transfected with rat connexin43 (Cx43). Using double cell voltage clamp technique in cardiomyocytes under control conditions, gap junction conductance (Gj) steadily decreased (by -0.3 to -0.4(More)
OBJECTIVE To examine how epicardial activation and repolarisation patterns change in the course of ischaemia, and how these changes are related to the underlying histological structures. METHODS Langendorff perfused isolated rabbit hearts were submitted to 30 minutes of left anterior descending coronary artery occlusion followed by 30 minutes of(More)
There is a need to reduce medication errors, and one way of achieving this for high-risk medications is by double-checking. This article reports the results of a literature review, undertaken as part of an MSc, which examined safe processes for double-checking. The article discusses three themes that emerged from the review: the evidence and processes of(More)
The leucine aminopeptidase (“LAP”) has been determined by an improved technique in blood smears of 125 normal subjects, 73 patients with Hodgkin's disease, 63 patients with other lympho-reticular disorders and blood dyscrasias and in 30 bone marrow smears of persons without haematologic diseases. The highest activity was found in basophile granulocytes and(More)
Because of the known higher incidence of cardiac arrhythmia in aged patients we tried to define the underlying arrhythmogenic substrate by quantifying those electrophysiological alterations in aged rabbit hearts, which are commonly believed to be arrhythmogenic, relating them to histological findings in the same hearts. This is the first investigation that(More)
Acetylsalicylic acid often is used in the treatment and prophylaxis of regional myocardial ischemia and infarction. However, only little is known about its electrophysiological effects and on possible proarrhythmic effects of the drug. Thus, the aim of this study was to evaluate the electrophysiological effects of acetylsalicylic acid in normal isolated(More)
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