Mary E. Lee

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The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract ClpP is a self-compartmentalized protease, which has very limited degradation activity unless it associates with ClpX or ClpA to form the AAA+ ClpXP or ClpAP proteases. Here, we show that ClpX binding stimulates ClpP cleavage of(More)
The author hereby grants to MIT permission to reproduce and to distribute publicly paper and electronic copies of this thesis document in whole or in part in any medium now known or hereafter created. ABSTRACT AAA+ self-compartmentalized proteases are an important class of proteome regulators that operate to selectively degrade protein substrates. All of(More)
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