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This work describes the development of a model of cerebral atrophic changes associated with the progression of Alzheimer's disease (AD). Linear registration, region-of-interest analysis, and voxel-based morphometry methods have all been employed to elucidate the changes observed at discrete intervals during a disease process. In addition to describing the(More)
Vascular endothelial growth factor (VEGF) is a regulator of vascularization in development and is a key growth factor in tissue repair. In disease, VEGF contributes to vascularization of solid tumors and arthritic joints. This study examines the role of the mRNA-binding protein AUF1/heterogeneous nuclear ribonucleoprotein D (AUF1) in VEGF gene expression.(More)
BACKGROUND Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glutamate antagonist memantine has been widely prescribed, often in the later stages of AD. Memantine is licensed for moderate to severe(More)
BACKGROUND Although less likely to be reported in clinical trials than expressions of the statistical significance of differences in outcomes, whether or not a treatment has delivered a specified minimum clinically important difference (MCID) is also relevant to patients and their caregivers and doctors. Many dementia treatment randomised controlled trials(More)
Trucking has been classified as one of the highest-risk occupations in the United States. Occupational stress is even greater for long-haul truckers who are away from home, family, friends, and other support networks for several days or weeks at a time. Occupational stressors and the mental health of truckers was studied using data collected as part of a(More)
  • Mary O 'brien, Sarah Webster, Angela Herrick, John Edwards, Terry Watt, Mark Jazo +25 others
  • 2007
Acknowledgments We gratefully acknowledge Jane Morgan and Patsy Buida at the Children's Bureau for their charge to develop this Framework, and their vision that this publication could assist child welfare agencies in preparing for and coping with disasters. Patsy Buida provided thoughtful comments and guidance throughout the process of developing the(More)
  • Marc Winokur, Ralph Longobardi, Graig Crawford, Deborah Valentine, Jim Drendel, Melisa Maling +14 others
  • 2006
Executive Summary This report presents a descriptive study of kinship care conducted by the Social Weld. The purpose of the study was to identify emergent trends to serve as points of emphasis for counties and the state of Colorado in developing policy and practice for kinship care. The study also was designed to inform an outcome study that will employ a(More)
BACKGROUND Due to frequent infections in cystic fibrosis (CF) patients, repeated respiratory cultures are obtained to inform treatment. When patients are unable to expectorate sputum, clinicians obtain throat swabs as a surrogate for lower respiratory cultures. There is no clear data in adult subjects demonstrating the adequacy of throat swabs as a(More)
  • Marc Winokur, Graig Crawford, Ralph Longobardi, Deborah Valentine, Jim Drendel, Melisa Maling +12 others
  • 2006
Pueblo, and Weld counties. The study employed a matched case design to compare children in kinship care with children in foster care on available child welfare outcomes. The total sample for the study was comprised of a cohort of 1377 children from the 12 counties who first entered out-of-home care in 2002, spent greater than 60 days in out-of-home care,(More)
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