Mary Catterall

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Epidermal growth factor receptor (EGFR) is amplified or overexpressed in many malignant gliomas and other primary brain tumors but is low or undetectable in normal brain. In the present study, this differential expression has been exploited for targeted brain tumor therapy using a TGF-alpha-Pseudomonas exotoxin recombinant toxin, TGF-alpha-PE38. In vitro(More)
Fast neutron therapy has been used to treat 87 tumours of primary, recurrent or metastatic melanoma in 48 patients. Complete regression has been obtained in 71 percent of tumours and 91 per cent of all tumours were controlled for the remainder of the patients, lives. Median survival was 14.5 months; 30 of the 34 deaths were due to metastases. Complications(More)
In patients who undergo radiotherapy for malignant disease in the region of the chest, the diagnosis of cardiac infarction has sometimes been entertained when chest pain has appeared as a prominent symptom during or after treatment. To resolve this diagnosis presupposes a knowledge of the effects of radiation upon the heart, and the changes that such(More)