Mary C Patton

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This year, pancreatic ductal adenocarcinoma (PDAC) is expected to overtake breast cancer to become the third leading cause of cancerrelated death in the United States [1]. Nearly 50,416 new cases and 41,780 deaths are estimated to occur in 2016. PDACs carry a notoriously poor prognosis due to advanced stage presentation in most patients and lack of(More)
Here we present the first oligonucleotide DNA microarray analysis of global gene expression changes in the obligate intracytoplasmic pathogen Rickettsia prowazekii using temperature upshift as a model stress condition, and we describe a methodology for isolating highly purified rickettsial RNA. In toto, 23 transcripts were significantly increased by(More)
Background:Chemoresistance is a significant clinical problem in pancreatic cancer (PC) and underlying molecular mechanisms still remain to be completely understood. Here we report a novel exosome-mediated mechanism of drug-induced acquired chemoresistance in PC cells.Methods:Differential ultracentrifugation was performed to isolate extracellular vesicles(More)
Stuffy nose, itchy and watery eyes, shortness of breath with wheezing, hives and stomach upsets often translate into allergic rhinitis, allergic asthma, urticaria and food allergies. These symptoms present a diagnostic dilemma to practitioners, even when sophisticated immunologic tests are available. Given a good history, however, the most common allergic(More)
OBJECTIVES Exosomes are important mediators in intercellular communications and play a role in cancer progression and metastasis. Exosomal membranes are enriched in endosome-specific tetraspanins (CD9 and CD63). Here, we explored the expression of CD63 and CD9 utilizing immunohistochemistry in malignant and nonmalignant cells in 29 resected pancreatic(More)
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