Mary C. MacLachlan

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The mechanisms underlying the ST segment shifts associated with subendocardial ischemia remain unclear. The aim of this paper is to shed further light on the subject through numerical simulations of these shifts. A realistic three-dimensional model of the ventricles, including fiber rotation and anisotropy, is embedded in a nonhomogeneous torso model. A(More)
It is well known that the presence of myocardial ischemia can be observed as a shift in the ST segment of an electrocardiogram (ECG) recording. The question we address in this paper is whether or not ST shift can be used to compute approximations of the size and location of the ischemic region. We begin by investigating a cost functional (measuring the(More)
Uniform Resource Agents (URAs) Status of this Memo This memo defines an Experimental Protocol for the Internet community. This memo does not specify an Internet standard of any kind. Discussion and suggestions for improvement are requested. Distribution of this memo is unlimited. Abstract This paper presents an experimental architecture for an agent system(More)
Mathematical models for the electrical activity in cardiac cells are normally formulated as systems of ordinary differential equations (ODEs). The equations are nonlinear and describe processes occurring on a wide range of time scales. Under normal accuracy requirements, this makes the systems stiff and therefore challenging to solve numerically. As(More)
Mathematical models of electric activity in cardiac tissue are becoming an increasingly powerful tool in the study of the heart and cardiac arrhythmias. The ordinary differential equations contained within these mathematical models are challenging to solve. This challenge often means that the physiological accuracy of a model is limited by how efficient we(More)
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