Mary C. MacLachlan

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The mechanisms underlying the ST segment shifts associated with subendocardial ischemia remain unclear. The aim of this paper is to shed further light on the subject through numerical simulations of these shifts. A realistic three-dimensional model of the ventricles, including fiber rotation and anisotropy, is embedded in a nonhomogeneous torso model. A(More)
It is well known that the presence of myocardial ischemia can be observed as a shift in the ST segment of an electrocardiogram (ECG) recording. The question we address in this paper is whether or not ST shift can be used to compute approximations of the size and location of the ischemic region. We begin by investigating a cost functional (measuring the(More)
Mathematical models for the electrical activity in cardiac cells are normally formulated as systems of ordinary differential equations (ODEs). The equations are nonlinear and describe processes occurring on a wide range of time scales. Under normal accuracy requirements, this makes the systems stiff and therefore challenging to solve numerically. As(More)
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