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Dopamine signaling modulates voluntary movement and reward-driven behaviors by acting through G protein-coupled receptors in striatal neurons, and defects in dopamine signaling underlie Parkinson's disease and drug addiction. Despite the importance of understanding how dopamine modifies the activity of striatal neurons to control basal ganglia output, the(More)
Maternal care is critical for the survival, development and long-term success of offspring. Despite our current understanding of the role of endogenous estrogen in both maternal behavior and the maternal brain, the potential effects of exogenous estrogens on these endpoints remain poorly understood. Here, pregnant CD-1 mice were exposed to low doses of(More)
Estrogenic endocrine disrupting chemicals have been shown to disrupt maternal behavior in rodents. We investigated the effects of an emerging xenoestrogen, bisphenol S (BPS), on maternal behavior and brain in CD-1 mice exposed during pregnancy and lactation (F0 generation) and in female offspring exposed during gestation and perinatal development (F1(More)
The number of chemicals identified as endocrine disruptors continues to rise, and, yet, many assays intended to prioritize them for further action cannot gauge their impact on cells. Stossi and colleagues present new high-throughput screening methods that inform estrogen receptor biology, leading to questions about "safe alternatives" for one compound,(More)
We present evidence for the Ðrst detection of gamma rays from the extragalactic object BL Lacertae. Observations taken with EGRET on the Compton Gamma Ray Observatory between 1995 January 24 and 1995 February 14 indicate a 4.4 p excess from the direction of BL Lacertae. The corresponding Ñux is (40 ^ 12) ] 10~8 photons cm~2 s~1 above 100 MeV. The(More)
RNA interference by feeding worms bacteria expressing dsRNAs has been a useful tool to assess gene function in C. elegans. While this strategy works well when a small number of genes are targeted for knockdown, large scale feeding screens show variable knockdown efficiencies, which limits their utility. We have deconstructed previously published RNAi(More)
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