Mary Barry

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OBJECTIVE Symptomatic carotid stenosis is associated with a 3-fold risk of early stroke recurrence compared to other stroke subtypes. Current carotid imaging techniques rely on estimating plaque-related lumen narrowing but do not evaluate intraplaque inflammation, a key mediator of plaque rupture and thromboembolism. Using combined (18) F-fluorodeoxyglucose(More)
In the special education context of children with autism, the design of educational software needs to focus on their unique learning styles. In this study, results of a survey in Irish Primary Schools, and interviews with tutors, indicate that characteristics of learners with autism need to be more integrated into the design process. An interaction model,(More)
BACKGROUND Polymorphic thiopurine S-methyltransferase (TPMT) is a major determinant of thiopurine toxicity. METHODS We extracted 6-thioguanine nucleotides (6-TGNs) and 6-methylmercaptopurine nucleotides (6-MMPNs) from erythrocytes with perchloric acid and converted them to 6-thioguanine (6-TG) and a 6-methylmercaptopurine (6-MMP) derivative during a(More)
Conjugated linoleic acid (CLA) has the unique property of inducing regression of pre-established murine atherosclerosis. Understanding the mechanism(s) involved may help identify endogenous pathways that reverse human atherosclerosis. Here, we provide evidence that CLA inhibits foam cell formation via regulation of the nuclear receptor coactivator,(More)
OBJECTIVE We hypothesized that serum lipids, which experimental data suggest may be key initiators of carotid plaque inflammation, would be associated with plaque inflammation on (18)fluorodeoxyglucose (FDG)-PET in patients with acutely symptomatic carotid stenosis. METHODS In this cohort study, consecutive patients with acute symptomatic internal carotid(More)
Weblogs can be used as a tool for learning support, providing additional features that are lacking in many Learning Management Systems (LMSs). This research aims to demonstrate that weblogs can enhance the learning experience by allowing students to reflect on their learning, and by allowing students to easily collaborate with their tutors and with one(More)
Dysregulation of inflammatory responses is a hallmark of multiple diseases such as atherosclerosis and rheumatoid arthritis. As constitutively active transcription factors, NR4A nuclear receptors function to control the magnitude of inflammatory responses and in chronic inflammatory disease can be protective or pathogenic. Within this study, we demonstrate(More)
Atherosclerosis is an inflammatory disease caused by endothelial injury, lipid deposition, and oxidative stress. This progressive disease can be converted into an acute clinical event by plaque rupture and thrombosis. In the context of atherosclerosis, the underlying cause of myocardial infarction and stroke, macrophages uniquely possess a dual(More)
Report Title: The design of a course in robotics to develop appreciation and awareness of technology and self. Acknowledgements The authors would like to thank the following people for their assistance and support in the compilation of this report, and in the project as a whole: Declaration This work is submitted in partial fulfilment of the requirements of(More)
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