Mary Anne Townsend

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The influence of tumor burden on the generation of tumor antigen-specific cytotoxic T-lymphocytes (CTL) was investigated in a phase I/II clinical adoptive immunotherapy trial. Four previously treated metastatic breast cancer patients, two with macroscopic disease and two with no evidence of disease, in complete remission (CR), were enrolled. Each apheretic(More)
Surgical gloves were introduced in the early years of this century, initially to protect nurses' and surgeons' hands from the strong antiseptic chemicals used during surgery. William Stewart Halstead is generally credited with introducing gloves to protect his scrub nurse (who later became his wife) from the carbolic acid in which the instruments were(More)
Many human adenocarcinomas can be killed in vitro by targeted cytotoxic T-lymphocytes (CTL); however, major histocompatibility complex (MHC)-restrictions are typically required. The MUC1 antigen is common in many human adenocarcinomas, and is associated with a variable number of tandem repeats. It has been proposed that antigens with such repeated epitopes(More)
The objective was to evaluate the toxicity and feasibility of intraperitoneal infusion of tumor-specific cytotoxic T lymphocytes (CTL) as therapy for recurrent ovarian cancer, and to determine if repetitive cycles of CTL generation and infusion measurably increases the host's ovarian cancer immune response. In this study, 7 subjects with recurrent ovarian(More)
BACKGROUND Apheresis platelet (AP) contamination may be influenced by manufacturing methods because bacteria are subject to the same forces that permit separation of blood cells. This study assesses whether apheresis technology influences in-process detection of bacterial contamination. STUDY DESIGN AND METHODS Blood Systems, Inc. (BSI) and New York Blood(More)
Pediatric reference intervals for biochemical tests are often derived from studies in Western countries and may not be applicable to the developing world. No such intervals exist for Melanesian populations. The aim of this study was to provide specific reference intervals for children from Papua New Guinea (PNG). We assayed plasma from 327 healthy(More)
In my previous article I looked at the quality of life that cardiac transplant patients have both before and after the actual operation. The quality of these patients' lives is, in nearly every case, extremely poor. Most (97%) are unable to work or even do everyday tasks such as housework, cooking and so on. A large number are housebound. Many of them(More)