Mary Ann Horton

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Transgenic mice were generated using regulatory elements from the CD3delta gene to drive T cell expression of IL-5. Expression of this cytokine resulted in white blood cell counts that expand virtually unabated (approximately 400,000 cells/mm3). This expansion is characterized by a profound eosinophilia (>60%) and commensurate increases in the absolute(More)
The final stage in the migration of leukocytes to sites of inflammation involves movement of leukocytes through the endothelial cell layer and the perivascular basement membrane. Both platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) and the integrin alphavbeta3 have been implicated in this process, and in vitro studies have identified(More)
The mouse eosinophil peroxidase (mEPO) gene was cloned by screening a random-primed bone marrow cDNA library at reduced criteria using a hEPO cDNA. An mEPO cDNA was subsequently used to isolate the mEPO gene from a lambda-genomic library. The mEPO gene displays a high degree of conservation with its human homologue: the transcription units are approximately(More)
The existence of a murine homologue of the major basic protein (MBP) found in human eosinophil granules was initially hypothesized from structural similarities at the electron microscopic level. The results presented in this study have extended these observations by describing the identification/purification of a mouse MBP (mMBP) and the cloning of the gene(More)
Thymocyte heterogeneity has been studied by the use of two cell surface markers--the Ly-6.2 alloantigen and peanut agglutinin (PNA) receptor. The previously described distribution of Ly-6 on corticoresistant and PNA binding to corticosensitive thymocytes has been confirmed. Double immunofluorescence labeling experiments in combination with techniques of(More)
This paper measures the incidence of Sex Reassignment Surgery (SRS) for US residents. It reports the number of US residents undergoing SRS in one calendar year (2001) using a survey of surgeons who offered SRS procedures. This run rate is used to calculate incidence of SRS, and to estimate prevalence. Estimates of incidence and inherent prevalence of Gender(More)
Sixty-six patients with Addisonian pernicious anaemia have been HLA typed and compared with 86 controls of the same ethnic group. No deviation in antigen frequency was found to be specific for the disease group as a whole. The most significant deviation found was an increased frequency of HLA-B8 in those patients with coincident thyroid autoantibodies.(More)
Severe neurological complications (either peripheral neuropathy, subacute combined degeneration of the cord or cerebral changes) are a characteristic feature in some patients with marked vitamin B12 deficiency. Although Addisonian pernicious anaemia (PA) is the major cause of this neurological syndrome, the disorder has been described in association with(More)
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