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The paper on the UNOS Liver Allocation Model (ULAM) describes the building of a simulation model that supports policy evaluation for a national medical problem. The modeling and simulation techniques used in building ULAM include: fitting donor and patient arrival processes having trend and cyclic rate components using non-homogeneous Poisson processes(More)
A graphical interactive technique for modeling bivariate simulation inputs is based on a family of continuous univariate and bivariate probability distributions with bounded support that are described by Be´zier curves and surfaces, respectively. This family of distributions has a natural, extensible parameterization so that all parameters have a(More)
New methods are presented for estimating univariate and bivariate Bezier distributions. A likelihood ratio test is used to estimate the number of control points for a univariate Bezier distribution fitted to sample data. To estimate the control points of a bivariate Bezier distribution with fixed marginals based on either sample data or subjective(More)
The genus Brucella consists of bacterial pathogens that cause brucellosis, a major zoonotic disease characterized by undulant fever and neurological disorders in humans. Among the different Brucella species, Brucella melitensis is considered the most virulent. Despite successful use in animals, the vaccine strains remain infectious for humans. To understand(More)
The virB genes coding type IV secretion system are necessary for the intracellular survival and replication of Brucella spp. In this study, extracellular proteins from B. abortus 2308 (wild type, WT) and its isogenic virB10 polar mutant were compared. Culture supernatants harvested in the early stationary phase were concentrated and subjected to 2D(More)
Techniques are presented for modeling and generating the univariate probabilistic input processes that drive many simulation experiments. Emphasis is on the generalized beta distribution family, the Johnson translation system of distributions, and the Bézier distribution family. Also discussed are nonparametric techniques for modeling and simulating(More)
Brucella melitensis is a facultative intracellular bacterial pathogen that causes brucellosis, a zoonotic disease primarily infecting sheep and goats, characterized by undulant fever, arthritic pain and other neurological disorders in humans. A comprehensive proteomic study of strain 16M was conducted to identify and characterize the proteins expressed in(More)
Techniques are presented for modelling and then randomly sampling many of the continuous univariate probabilistic input processes that drive discrete-event simulation experiments. Emphasis is given to the generalized beta distribution family, the Johnson translation system of distributions, and the Be´zier distribution family because of the flexibility of(More)
Brucella species are pathogenic agents that cause brucellosis, a debilitating zoonotic disease that affects a large variety of domesticated animals and humans. Brucella melitensis and Brucella abortus are considered major health threats because of their highly infectious nature and worldwide occurrence. The availability of the annotated genomes for these(More)