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Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient receptor potential (TRP) family of ion channels has… Expand
Melanopsin Is Required for Non-Image-Forming Photic Responses in Blind Mice
Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells. These cells express melanopsin,… Expand
Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate
- A. Moqrich, Taryn J. Earley, +6 authors A. Patapoutian
- Biology, Medicine
- Nature Neuroscience
- 11 July 2004
Tactile information is perceived by a heterogeneous population of specialized neurons. Neurotrophin receptors (the receptor tyrosine kinases, Trks) mark the major classes of these sensory neurons:… Expand
Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.
We describe the biological properties of a new class of potent farnesyltransferase (FT) inhibitors designed as bisubstrate analog inhibitors. These inhibitors incorporate the structural motifs of… Expand
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
- K. Leftheris, T. Kline, +19 authors V. Manne
- Chemistry, Medicine
- Journal of medicinal chemistry
- 5 January 1996
Analogs of CVFM (a known nonsubstrate farnesyltransferase (FT) inhibitor derived from a CA1A2X sequence where C is cysteine, A is an aliphatic residue, and X is any residue) were prepared where… Expand
Impaired thermosensation in mice lacking TRPV3
In a method for testing a continuously forward-moving strand a light beam which passes along a plane that extends approximately perpendicularly to the longitudinal axis of the strand is introduced… Expand
Selection of primary cell cultures with cre recombinase induced somatic mutations from transgenic mice.
- K. Zeh, M. Andahazy, S. O'Gorman, H. Baribault
- Biology, Medicine
- Nucleic acids research
- 1 September 1998
Deletion of genes in defined cell types has been achieved using a combination of gene targeting techniques and the Cre- lox P recombination system. Here we present a method to selectively isolate… Expand