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Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient receptor potential (TRP) family of ion channels hasExpand
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Melanopsin Is Required for Non-Image-Forming Photic Responses in Blind Mice
Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells. These cells express melanopsin,Expand
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Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate
Tactile information is perceived by a heterogeneous population of specialized neurons. Neurotrophin receptors (the receptor tyrosine kinases, Trks) mark the major classes of these sensory neurons:Expand
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Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.
We describe the biological properties of a new class of potent farnesyltransferase (FT) inhibitors designed as bisubstrate analog inhibitors. These inhibitors incorporate the structural motifs ofExpand
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Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
Analogs of CVFM (a known nonsubstrate farnesyltransferase (FT) inhibitor derived from a CA1A2X sequence where C is cysteine, A is an aliphatic residue, and X is any residue) were prepared whereExpand
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Impaired thermosensation in mice lacking TRPV3
In a method for testing a continuously forward-moving strand a light beam which passes along a plane that extends approximately perpendicularly to the longitudinal axis of the strand is introducedExpand
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Selection of primary cell cultures with cre recombinase induced somatic mutations from transgenic mice.
Deletion of genes in defined cell types has been achieved using a combination of gene targeting techniques and the Cre- lox P recombination system. Here we present a method to selectively isolateExpand
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