Marwa Ammar

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Mitochondrial diseases are a heterogeneous group of disorders caused by the impairment of the mitochondrial oxidative phosphorylation system which have been associated with various mutations of the mitochondrial DNA (mtDNA) and nuclear gene mutations. The clinical phenotypes are very diverse and the spectrum is still expanding. As brain and muscle are(More)
Multi-Agent System (MAS) is a very active field that ensures global coherence between agents' interactions in a distributed way and implicit global control. Under the awareness of its power, the application of MAS was no more limited to very specific problems, but to almost application area: optimization, neural network, robotics, fuzzy system, etc. In the(More)
This paper proposes two hybrid optimization methods based on Harmony Search algorithm (HS) and two different nature-inspired metaheuristic algorithms. In the first contribution, the combination was between the Improved Harmony Search (IHS) and the Particle Swarm Optimization (PSO). The second contribution merged the IHS with the Differential Evolution (DE)(More)
The major issue of researchers in ANN field is the optimization of the training process including time cost and NN structure. In response to the long training time, Multi-Agent architecture of feed forward Flexible Neural Tree model (MAFNT) is introduced for parallelizing the NN training. Moreover, looking for the best topology of NN, for a given problem,(More)
Mitochondrial diseases caused by mitochondrial dysfunction are a clinically and genetically, heterogeneous group of disorders involving multiple organs, particularly tissues with high-energy demand. Hearing loss is a recognized symptom of a number of mitochondrial diseases and can result from neuronal or cochlear dysfunction. The tissue affected in this(More)
Mitochondrial diseases encompass a wide variety of pathologies characterized by a dysfunction of the mitochondrial respiratory chain resulting in an energy deficiency. The respiratory chain consists of five multi-protein complexes providing coupling between nutrient oxidation and phosphorylation of ADP to ATP. In the present report, we studied mitochondrial(More)