Martine Verdière

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HA, besides its function in immune processes, is probably a neurotransmitter in mammalian brain. It is synthesized by a specific decarboxylase localized in the cytoplasm of nerve endings. It is stored in synaptic vesicles. Its release might depend on nerve-impulse flow; specific receptors to this amine have been evidenced both electrophysiologically and by(More)
In primary cell cultures of rat superior cervical ganglia the tailed, asymmetric 16S molecular form of acetylcholinesterase (AChE) is preferentially decreased after potassium depolarization. This effect is not related to noradrenergic differentiation elicited by high potassium concentration. Moreover there is a partial antagonist action of a calcium-channel(More)
s of the Meeting of the Histamine Club 1975 469 Decreased Turnover of Histamine in the Brain of Restrained Mice by MARTINE VERDI~RE, CHRISTIANE ROSE and J.-C. SCHWARTZ Unit6 de Neurobiologie de I'INSERM, 2 ter rue d'A16sia, 75014 Paris, France Conflicting reports appeared during the last years about the effects of stress on brain histamine. TAYLOR and(More)
In slices from rat hypothalamus, incubated in the presence of 3H-L-histidine (3H-L-His), the aminoacid was rapidly taken up by a saturable process, and partially converted into 3H-histamine (3H-HA). The overall conversion was prevented either by inhibitors of L-histidine decarboxylase or by aromatic aminoacids competing with L-His uptake. The synthesis(More)
Acetylcholinesterase activity was detected in the carotid labyrinth of amphibians by both biochemical and histochemical methods. The histochemical tests showed enzyme activity in surfaces of afferent and efferent nerve terminals in contact with type I cells, but none within the type I cells. Acetylcholinesterase activity occurred on some, though not all,(More)
macological or surgical means. Vagotomy (with pyloroplasty to prevent gastric dilatation), or treatment with atropin, hexamethonium, deglycyrrhizinized liquorice, prostaglandin E1 or 'antigastrin' (SC 15396), which all inhibited acid secretion, were found to induce a marked increase in enzyme activity in fasted normal rats. After antrectomy, which(More)
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