Martine T. B. Truijman

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PURPOSE To investigate the natural history of carotid atherosclerosis in patients who experienced a TIA or ischemic stroke. PATIENTS AND METHODS Ninety-two TIA/stroke patients (57 men, mean age 67.7 ± 9.8 years) with ipsilateral <70% carotid stenosis underwent multisequence MRI of the plaque ipsilateral to the symptomatic side at baseline and after one(More)
BACKGROUND AND PURPOSE Hallmarks of vulnerable atherosclerotic plaques are inflammation that can be assessed with 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography, and increased neovascularization that can be evaluated by dynamic contrast-enhanced-MRI. It remains unclear whether these parameters are correlated or represent(More)
PURPOSE Atherosclerotic carotid plaques can be quantified in vivo by MRI. However, the accuracy in segmentation and quantification of components such as the thin fibrous cap (FC) and lipid-rich necrotic core (LRNC) remains unknown due to the lack of a submillimeter scale ground truth. METHODS A novel approach was taken by numerically simulating in vivo(More)
Automated segmentation of plaque components in carotid artery magnetic resonance imaging (MRI) is important to enable large studies on plaque vulnerability, and for incorporating plaque composition as an imaging biomarker in clinical practice. Especially supervised classification techniques, which learn from labeled examples, have shown good performance.(More)
BACKGROUND AND PURPOSE In patients with mild to moderate symptomatic carotid artery stenosis, intraplaque hemorrhage (IPH) and a thin/ruptured fibrous cap (FC) as evaluated with MRI, and the presence of microembolic signals (MESs) as detected with transcranial Doppler, are associated with an increased risk of a (recurrent) stroke. The objective of the(More)
C arotid atherosclerosis is an important cause of ischemic stroke. Assessment of plaque composition in addition to degree of luminal stenosis can be used to identify patients with increased risk of stroke and assess disease progression. Magnetic resonance imaging (MRI) is an excellent noninva-sive imaging technique to assess vessel wall morphology and(More)
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