Martine Piaser

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There are several pathogenic mechanisms of peripheral nerve involvement in patients with monoclonal dysglobulinemia. Intranervous proliferation of malignant cells, immunoglobulin, or amyloid deposits in the endoneurial space can only be determined by examination of nerve biopsy specimens. We present clinical, electrophysiological, and histological data from(More)
A variety of immunocytochemical techniques are now widely used for the electron and light microscopic examination of biological samples. They are employed routinely for investigating the role of certain proteins in nervous tissue. Immunoelectron microscopic studies require the tissue to be fixed and embedded in a solid support, which may disrupt cellular(More)
The myelin-associated glycoprotein (MAG) possesses two isoforms, known as S-MAG and L-MAG. We followed the expression and localization of L-MAG in comparison to myelin basic protein (MBP) during myelination in dissociated embryonic rat brain cell cocultures. Using immunofluorescence microscopy, we observed L-MAG and MBP in oligodendrocyte (OL) cell bodies(More)
The amount of myelination in vivo and in vitro depends on the number of oligodendrocyte progenitors, their differentiation, and on the neuron function. It has been shown that continuous administration of FGF2, a mitotic and neuroprotective factor, allows oligodendrocyte progenitors to proliferate, but prevents them from differentiating and myelinating. This(More)
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