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  • Christos Sotiriou, Pratyaksha Wirapati, +17 authors Mauro Delorenzi
  • Medicine
  • Journal of the National Cancer Institute
  • 2006 (First Publication: 15 February 2006)
  • BACKGROUND Histologic grade in breast cancer provides clinically important prognostic information. However, 30%-60% of tumors are classified as histologic grade 2. This grade is associated with anContinue Reading
  • Christine Desmedt, Fanny Piette, +17 authors Christos Sotiriou
  • Medicine
  • Clinical Cancer Research
  • 2007 (First Publication: 1 June 2007)
  • Purpose: Recently, a 76-gene prognostic signature able to predict distant metastases in lymph node–negative (N−) breast cancer patients was reported. The aims of this study conducted by TRANSBIG wereContinue Reading
  • Sherene Loi, Benjamin Haibe-Kains, +14 authors Christos Sotiriou
  • Biology, Medicine
  • Journal of clinical oncology : official journal…
  • 2007 (First Publication: 1 April 2007)
  • PURPOSE A number of microarray studies have reported distinct molecular profiles of breast cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like subtypes. These were associatedContinue Reading
  • Sherene Loi, Nicolas Sirtaine, +13 authors Christos Sotiriou
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2013 (First Publication: 1 March 2013)
  • PURPOSE Previous preclinical and clinical data suggest that the immune system influences prognosis and response to chemotherapy (CT); however, clinical relevance has yet to be established in breastContinue Reading
  • Paul E Goss, James N. Ingle, +15 authors Joseph L. Pater
  • Medicine
  • Journal of the National Cancer Institute
  • 2005 (First Publication: 7 September 2005)
  • BACKGROUND Most recurrences in women with breast cancer receiving 5 years of adjuvant tamoxifen occur after 5 years. The MA.17 trial, which was designed to determine whether extended adjuvant therapyContinue Reading
  • Nathan I. Cherny, Richard Sullivan, +5 authors Martine J. Piccart
  • Medicine
  • Annals of oncology : official journal of the…
  • 2015 (First Publication: 1 August 2015)
  • The value of any new therapeutic strategy or treatment is determined by the magnitude of its clinical benefit balanced against its cost. Evidence for clinical benefit from new treatment options isContinue Reading