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Rab2 promotes autophagic and endocytic lysosomal degradation
Rab7 promotes fusion of autophagosomes and late endosomes with lysosomes in yeast and metazoan cells, acting together with its effector, the tethering complex HOPS. Here we show that another smallExpand
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Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries
The ability of cells to alter their phenotypic and morphological characteristics, known as cellular plasticity, is critical in normal embryonic development and adult tissue repair and contributes toExpand
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  • Open Access
Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis
Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of RAS GEF catalysis have been unveiled,Expand
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A NUMB–EFA6B–ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility
The endocytic protein NUMB has been implicated in the control of various polarized cellular processes, including the acquisition of mesenchymal migratory traits through molecular mechanisms that haveExpand
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  • Open Access